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BIOCATALYSIS IN DEVELOPMENT OF GREEN PHARMACEUTICAL PROCESSES – AN ENGINEERING APPROACH

The pharmaceutical industry is viewed as the one having the highest environmental impact [1]. Pharmaceutical companies are increasingly making public commitments to sustainability goals and investing in "green" chemistry and the equipment and manufacturing practices needed to meet these goals. That is why they require new synthetic routes to be environmentally compatible, as well as to fulfil the demands of process economics, product specification and to continually reduce development times. Biocatalysis has the potential to deliver these demands and make chemical syntheses "greener" [2]. It has long been recognized as a technology with great potential, as it was estimated in 2005 that there were around 150 implemented biocatalytic processes in industry, the majority being in the pharmaceutical sector [3]. The use of biocatalysis in industry continues to expand as a result of increased access to enzymes and the ability to engineer those enzymes to meet the demands of industrial processes [4]. Besides its extraordinary potential in the production of enantiopure compounds, and the ability to perform reactions that result in high substrate conversions and product yields, biocatalysis can also lower the consumption of chemicals, energy, solvents etc. Biocatalytic synthesis of pharmaceuticals can sucessfully compete with traditional methods in organic chemistry in economic and environmental aspects. That is why the number of biocatalytic processes in pharmaceutical industry continues to increase. In this lecture the focus will be put on different engineering strategies and discoveries that helped the implementation of biocatalysis to industry. The potential of chemical engineering strategies will also be demonstrated. [1] Sheldon RA, R. Soc. Interface 13 (2016) 20160087. [2] Woodley JM, Trends in Biotechnology, 26 (6) (2008) 321-327. [3] Panke S, Wubbolts M, Curr. Opin. Chem. Biol. 9 (2005) 188–194. [4] Truppo MD, ASC Medicinal Chem. Lett. 8(5) (2017) 476-483.

biocatalysis, mathematical modeling, cascade reaction, enzyme, optimization

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