Ascorbic acid – black hole of urine chemistry screening (CROSBI ID 253901)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Unic, Adriana ; Nikolac Gabaj, Nora ; Miler, Marijana ; Culej, Jelena ; Lisac, Adriana ; Horvat, Anita ; Vrkic, Nada
engleski
Ascorbic acid – black hole of urine chemistry screening
Study was performed in order: (i) to assess the comparability of glucose, bilirubin, hemoglobin, leukocyte esterase, and protein ; (ii) to assess accuracy of glucose, bilirubin, hemoglobin, leukocyte esterase, and protein ; and (iii) to evaluate interference of ascorbic acid on the glucose, bilirubin, hemoglobin, and nitrite determination using 2 different dipsticks: iChem Velocity, Iris Diagnostics and Combur-10M, Roche Diagnostics. Random urine specimens were included in the study. Comparability, accuracy, and ascorbic acid interference testing were performed. Obtained results have shown almost perfect agreement for all parameters between 2 dipsticks in samples with negative ascorbic acid. Agreement in samples with positive ascorbic acid was not acceptable for bilirubin, protein, nitrite, and hemoglobin. Accuracy was not acceptable for hemoglobin and leukocyte esterase on both dipsticks. Ascorbic acid interference examination has shown that intensity of interference differs between dipsticks. Ascorbic acid interferes with glucose, hemoglobin, nitrite, and bilirubin at different concentrations causing false-negative results. Obtained results indicate that it is necessary to determine diagnostic accuracy of used dipstick in order to define purpose of urinalysis. It is very important to choose dipstick with ascorbic acid indicator and to examine ascorbic acid impact on dipstick analytes independently of manufacturer claims.
Urinalysis ; Diagnostic accuracy ; Interference ; Ascorbic acid
Rad/časoois indeksiran je i u: Natural Science Collection ; Nutrition Abstracts & Reviews Series A ; ProQuest Central ; Public Health Database ; PubMed Dietary Supplement Subset ; SciTech Premium Collection.
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Podaci o izdanju
32 (5)
2018.
e22390
8
objavljeno
0887-8013
1098-2825
10.1002/jcla.22390
Povezanost rada
Kliničke medicinske znanosti, Farmacija