The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats (CROSBI ID 254669)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Oršolić, Nada ; Nemrava, Johann ; Jeleč, Željko ; Kukolj, Marina ; Odeh, Dyana ; Terzić, Svjetlana ; Fureš, Rajko ; Bagatin, Tomica ; Bagatin, Dinko
engleski
The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats
Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Proanthocyanidins and icariin have beneficial effects on bone health ; they have improved the bone weight reduction, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD), the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All results suggest that proanthocyanidins and icariin reverse osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by their antioxidative and estrogenic-like activity without toxic side-effects observed in ALN treatment.
proanthocyanidins ; icariin ; retinoic acid-induced bone loss ; rats ; bone markers
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Podaci o izdanju
19 (9)
2018.
2746
19
objavljeno
1422-0067
10.3390/ijms19092746