Treatment and skin decontamination of sarin intoxicated mice (CROSBI ID 256482)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vučemilović, Ante ; Hadžija, Mirko ; Žuntar, Irena
engleski
Treatment and skin decontamination of sarin intoxicated mice
This study aimed at evaluating the efficacy of oral treatment and skin decontamination with the mineral cationic carrier in sarin-intoxicated mice. Mice were contaminated with increasing percutaneous sarin doses and decontaminated. Furthermore, the surviving mice were treated per os. The behavioral patterns of the surviving animals were monitored for 72 h, including the animals ’ posture, desire for food and water, and approach and touch response. The results showed the mineral cationic carrier to be capable of efficiently decontaminating animals percutaneous poisoned with triple lethal dose. The comparison of behavioral pattern of control animals against those treated per os showed statistically significant differences. Oral treatment with mineral cationic carrier may be a detoxification tool against nerve agents ’ poisoning, and this merits further research.
Treatment ; mice ; mineral cationic carrier (MCC) ; sarin ; skin decontamination
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Podaci o izdanju
100 (3)
2018.
361-371
objavljeno
0277-2248
1029-0486
10.1080/02772248.2018.1523413
Povezanost rada
Biologija, Temeljne medicinske znanosti, Farmacija