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izvor podataka: crosbi

Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A (CROSBI ID 259384)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Domijan, Ana-Marija ; Marjanović Čermak, Ana Marija ; Vulić, Ana ; Tartaro Bujak, Ivana ; Pavičić, Ivan ; Pleadin, Jelka ; Markov, Ksenija ; Mihaljević, Branka Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A // Journal of environmental science and health. Part B, 54 (2019), 3; 155-162. doi: 10.1080/03601234.2018.1536578

Podaci o odgovornosti

Domijan, Ana-Marija ; Marjanović Čermak, Ana Marija ; Vulić, Ana ; Tartaro Bujak, Ivana ; Pavičić, Ivan ; Pleadin, Jelka ; Markov, Ksenija ; Mihaljević, Branka

engleski

Cytotoxicity of gamma irradiated aflatoxin B1 and ochratoxin A

Toxicity of gamma irradiated mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) was investigated in vitro. AFB1 and OTA stock solutions (50 mM, in methanol) were gamma irradiated (5 and 10 kGy) and non-irradiated and irradiated mycotoxins solutions were tested for cytotoxicity on Pk15, HepG2 and SH-SY5Y cell lines (MTT assay, 1–500 lM concentration range ; 24 h exposure). Degradation of mycotoxin molecules was examined by liquid chromatography tandem mass spectrometry (HPLC-MS/MS). AFB1 and OTA radiolytic products were less toxic than the parent mycotoxins to all of the tested cell lines. Gamma irradiation even at 5 kGy had effect on AFB1 and OTA molecules however, this effect was dependent on chemical structure of mycotoxin. Since gamma irradiation at low dose reduced initial level of both mycotoxins, and gamma irradiated mycotoxins had lower toxicity in comparison to non-irradiated mycotoxins, it can be concluded that gamma irradiation could be used as decontamination method.

cytotoxicity ; food safety ; gamma irradiation ; mycotoxins ; reduction

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Podaci o izdanju

54 (3)

2019.

155-162

objavljeno

0360-1234

1532-4109

10.1080/03601234.2018.1536578

Povezanost rada

Kemija, Biologija, Farmacija

Poveznice
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