engleski

Marek's disease vaccination, with turkey herpesvirus, and enrofloxacin modulate the activities of hepatic microsomal enzymes in broiler chickens

Chickens were vaccinated against Marek's disease intramuscularly at one day of age. Enrofloxacin was given ad libitum in the drinking water at concentration of 50, 100 and 250 mg/L from 8 days to 13 days of age when the animals were killed and the activities of cytochrome P-45o enzymes in the liver were measured. Vaccinated non-treated chickens served as a positive control. A negative control group was neither vaccinated nor treated. Vaccination decreased the activity of aniline hydroxylase and ethylmorphine N-demethylase in the positive control group. Subsequent application of enrofloxacin in the lowest concentration (50 mg/L) decreased, while that given at the higest level (250 mg/L) significantly increased the activity of he some microsomal enzymes. Relative liver weigths and concentrations of proteins in 9000 x g supernatant were not affected by vaccination or treatment.

Marek's disease vaccine; turkey herpesvirus; enrofloxacin; hepatic microsomal enzymes; broiler chickens

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