engleski

The role of noninherited HLA haplotypes in inducing donor-specific hyporesponsiveness

The ultimate goal of clinical transplantation is the induction of donor-specific unresponsiveness to MHC antigens without the impairment of host defense mechanisms. One possible route to a tolerance assay my be through a better understanding of mechanisms involved. Recent study have suggested that exposure of the fetus and newborn to noninherited maternal HLA antigens has a life-long effect on allograft recognition that could influence tolerance of organ grafts.

HLA haplotypes; CTLp; kidney transplantation

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