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"Cerebral" diabetes - is it connected to diabetes mellitus?

Diabetes mellitus is accompanied by alterations of the central nervous system. In animals with experimental diabetes caused by alloxan or streptozotocin, we found regionally specific changes of monoamine content, turnover rate, its transporters and receptors, pronounced in striatum and hypothalamus. Similar changes were observed in brain regions of diabetic patients post mortem.Unexpectedly, we also found similar brain monoamine changes in animals intracerebroventricularly (icv) treated with alloxan and streptozotocin, although these animals were not diabetic.Betacytotoxic-icv treated animals develop a kind of "cerebral" diabetes, known in the literature to have cognitive and glucose metabolism dysfunction similar to that seen in the sporadic Alzheimer's disease. The connection between the "cerebral" diabetes and diabetes mellitus is discussed.

cerebral diabetes; monoamines; Alzheimer's disease

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