Erythromelalgia (CROSBI ID 105404)
Prilog u časopisu | pregledni rad (stručni)
Podaci o odgovornosti
Ljubojević, Suzana ; Lipozenčić, Jasna ; Pustišek, Nives
engleski
Erythromelalgia
Erythromelalgia (EM) is a rare poorly understood clinical condition that is characterized by intense burning pain, pronounced erythema, and increased skin temperature. Although there are many classifications of the disease, it can basically be divided into primary which begins spontaneously at any age, and secondary, which is associated with myeloproliferative disorders-related thrombocythemia, polycythemia, collagen-vascular diseases, diabetes mellitus, peripheral neuropathy, autoimmune and infectious diseases, use of certain medicaments. A wide variety of etiological conditions can cause EM, but one common pathogenetic mechanism, microvascular arteriovenous shunting, has been hypothesized. It is characterized by severe pain associated with redness and hotness in extremities. The diagnosis is based on the medical history and clinical findings. The most useful oral medications for erythormelalgia appear to be aspirin, propranolol, clonazepam, cyproheptadine, drugs inhibiting serotonin reuptake (venlafaxine and sertraline), tricyclic antidepressants (amitriptyline, imipramine), anticonvulsans (gabapentin), calcium antagonists (nifedipine, diltiazem), prostaglandins (micoprostol). Erythromelalgia is usually chronic, sometimes progressive and disabling disease and it can greatly affect the quality of life. Some patients have stable course and get better or even experience full resolution of erythromelalgia with time. This review article presents the etiological basis, diagnostics, and therapy of erythromelalgia.
erythromelalgia; disease classification; pathogenesis; treatment
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