engleski

Concomitant respiratory allergy in atopic

Previous studies showed that similar mechanisms were involved in the pathogenesis of atopic diseases, e.g., allergic bronchial asthma (AB), allergic rhinoconjunctivitis (AR), and atopic dermatitis (AD). Because of the similarity of these diseases, there is a proposal to distinguish three main subtypes of AD: "mixed" type with concomitant respiratory allergy (RA), "extrinsic" type of "pure" AD without RA, but with allergen-specific IgE, and "intrinsic" type without immediate type sensitizations. The aim of this study was to determine the difference of test results between patients with "pure" AD (10) and "mixed" AD (20). There were 30 AD patients investigated. The parameters for monitoring were personal and family history cutaneous test: skin prick, scratch and patch test and values of total serum immunoglobulin E made according standard European procedures. The results showed the age of onset mostly in the early infancy [15 (50%) patients had developed the disease while under the age of 2 - 2/10 in "pure" AD, and 13/20 in "mixed" AD]. Twenty of them (66.6%) had a history of RA ("mixed" AD) whereas the remaining 10 (33.3%) had "pure" AD. Seventeen (56.6%) of AD patients also had 1 allergic disease, while 3 (10%) had two conditions (AR and AB). Family history was positive for atopy in 22(73.3%) AD patients [14 (46.6%) patients in a first-degree relative]. Twenty-four (80%) patients had positive prick tests [9/10 (90%) in "pure" AD, and 15/20 (75%) in "mixed" AD], mostly to house dust (20). Scratch test reactions were positive in 4 out of 10 patients (40%) in "pure" AD and 12/20 (60%) with "mixed" AD. Patch test reactions were positive in 50% "pure" AD patients and in 70% with "mixed" AD. AD patients had higher serum IgE (21/30) but similar in "pure" AD, and "mixed" AD [7/10 (70%) in "pure" AD, and 14/20 (70%) in "mixed" AD]. No statistically significant differences (p<0.05) between the "pure" AD and "mixed" AD patient groups were found, except for the age of disease onset being lower in the group of patients with concomitant RA. The results of our study did not show any difference in the allergologic parameters and the status between AD patients with concomitant RA and those without RA.

Atopic dermatitis

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