engleski

Role of the immune system in development of bone phenotype associated with generalised lymphoproliferative disorder in mice

We aimed to determine if the increased bone mass in mice with generalized lymphoproliferative disorder (gld), due to non-functional Fas-ligand , was a consequence of their autoimmune disorder, characterised by accumulation of double negative T cells (dnT) and production of autoantibodies. Parabiosis surgery was peformed betwen gld and wild-type mice. The jopint circulation in parabiosis leads to transfer of dnT cells from gld to wild-type animals and their homing to lympatic organs. Subsequent changes in the number of bone specific cells in bone marrow cultures of wild-type mice indicate that the bone phenotype of gld mice might be caused by their autoimmune disorder.

bone ; mice ; immune system

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